A new species of Megophrys (Amphibia: Anura: Megophryidae), Megophrys tuberogranulatus Shen, Mo et Li, sp. nov. (Holotype HNUL 03080902, adult male, SVL: 38.2 mm), from Sangzhi County, Hunan Province, is described. Megophrys tuberogranulatus is closely related to both Megophrys kuatunensis and Megophrys minor. Characters of the new species that differentiate this species from close relatives are skin granulated with big tubercles on the dorsal sides of both thigh and tibia, the bigger inner metacarpal tubercle, upper eyelid wider than the interorbital space, hind limbs longer, overlapping of the left and right calcaneal parts. The type specimens are deposited in the Animal Museum of Life Sciences College of Hunan Normal University [Current Zoology 56 (4): 432–436, 2010].